Sr. Associate Scientist/ Scientist – Antibody Discovery

Redmond, WA

About the position

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

The Sr Associate Scientist/Scientist is responsible for the discovery and development of novel antibody therapeutics. This position requires broad expertise in cell biology and a vested interest in using large diversity libraries for antibody discovery. The position requires a strong interest in bench work and hands-on cell culture experiments.

Essential Duties and Responsibilities

  • Support therapeutic antibody lead selection using multiple antibody discovery platforms
  • Design and execute immunization campaigns for specific immuno-oncology targets
  • Work in a fast-paced team environment to identify antibodies to desired targets within company timelines
  • Perform multiparametric flow cytometric analysis of mammalian cells in a high-throughput manner
  • Ability to perform fluorescence-based sorting of yeast and mammalian cells
  • Prepare and generate yeast display libraries for the selection of antibodies against desired targets
  • Assist with routine maintenance and operation of cell sorter
  • Use a variety of methods to determine antibody kinetics, affinity, and specificity
  • Prioritize work on multiple projects, support, and closely work with other divisions to advance company goals
  • Plan experiments, outline research procedures to be followed and provide training to subordinate personnel to carry out research
  • Ability to follow Standard Operating Procedures and effectively document and present results to colleagues
  • Work with other internal research departments and development groups in China. Plan time to accommodate meetings and technical support
  • Other duties as assigned.

Qualifications

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education and Experience
  • Ph.D. degree with 4 or more years of antibody discovery and characterization.
  • Strong scientific background in multiparametric flow cytometry and complex cell sorting (minimum 3 years).
  • History of research involving RNA extraction and cloning.
  • Experience in yeast culture and building antibody libraries is desired.
Language Ability
  • Ability to read and comprehend simple instructions, short correspondence, and memos.
  • Ability to write simple correspondence.
  • Ability to effectively present information in one-on-one and small group situations to customers, clients, and other employees of the organization.
  • Strong interpersonal, communication, and collaboration skills to connect with internal and external CROs.
  • Ability to read or write in Mandarin is a plus.
Math Ability
  • Ability to calculate figures and amounts such as discounts, interest, commissions, proportions, percentages, area, circumference, and volume.
  • Ability to apply concepts of basic algebra and geometry.
Reasoning Ability
  • Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form.
  • Strong scientific, medical, and analytical abilities with innovative, solution-oriented style.
Computer Skills

Proficiency with Microsoft Word, Excel, and Access required. Proficiency with email required.

Certificates and Licenses

None required.

Supervisory Responsibilities

This job may have supervisory responsibilities.

Work Environment
  • The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
  • This individual will work in cell culture and molecular biology laboratories alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.
Physical Demands
  • The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
  • While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to handle, assemble and manipulate bioreactor components and operate standard laboratory and business equipment.
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