Antibody Discovery and Protein Engineering Principal Scientist

Redmond, WA

Summary:

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

We are seeking a talented Principal Scientist with extensive experience in antibody-based therapeutics, in Antibody Discovery and Protein Engineering Department. The successful candidate will have a tracked record of antibody discovery humanization, engineering, molecular biology, purification and characterization.

Essential Duties and Responsibilities:

  • Oversee antibody discovery, humanization, engineering and characterization for novel therapeutic multi-specific antibodies and Antibody Drug Conjugate (ADC).
  • Lead and establish protein Structure – Function – Stability platform
  • In-depth experience in protein modeling and computational design
  • Responsible for candidate optimization, selection, and validation.
  • Hands on in homology modeling, mammalian expression, surface plasmon resonance, flow cytometry, SDS-PAGE are required
  • Proficiency with Pymol, IgBlast, Discovery Studio, abYsis, Geneious are required
  • Proven experience in mentorship and team management
  • Prepare and review Standard Operating Procedures (SOP)
  • Support and closely work with other divisions to advance company goals
  • Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China
  • Participate in timeline planning and decision making regarding research priorities of company or department and provide information on feasibility of prospective projects.
  • Other duties as assigned.

Qualifications:

To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education & Experience

  • PhD in Molecular Biology, Structural Biology, Biochemistry or a related field with 8+ years (PhD) of relevant academic and/or pharmaceutical or biotech experience
  • Strong fundamental knowledge and experience in antibody discovery, humanization and engineering
  • Extensive experience with homology modeling and structure-base design
Are you interested in this position? Apply now