About the position
Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.
Summary: The Director, Antibody Discovery & Protein Engineering will be responsible for leading a group of scientists to design, immunize, engineer and characterized antibody drug candidates – in the format of ADC, bispecific and multi-specific antibodies.
Essential Duties and Responsibilities:
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Lead the antibody discovery and protein engineering technologies,
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Oversee the integration of new antibody drug development technologies with novel antibody formats
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Responsible for antibody discovery immunization strategy and candidate validation
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Lead antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs).
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Use structural and sequence analysis to guide the design of drug candidates
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Oversee drug candidate optimization, selection, validation, and stability study
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Contributions to regulatory filings of biotherapeutics
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Review and authorize Standard Operating Procedures (SOP)
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Prepare reports and papers of completed projects for publication in technical journals, patents, presentation to regulatory agencies or at conferences, or use in further research activities.
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Support and closely work with other departments
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Work with R&D center in China. Plan time to accommodate meetings and technical support with team members in China
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Support scientific discussions, high-level strategic scientific advice, inputs, and expertise to management, the Board, advisory groups, and scientific committees.
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Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects.
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Other duties as assigned.
Qualifications:
To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.