Director, Antibody Discovery & Protein Engineering

Redmond, WA

About the position

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor. 

Summary: The Director, Antibody Discovery & Protein Engineering will be responsible for leading a group of scientists to design, immunize, engineer and characterized antibody drug candidates – in the format of ADC, bispecific and multi-specific antibodies.   

Essential Duties and Responsibilities: 

  • Lead the antibody discovery and protein engineering technologies,  

  • Oversee the integration of new antibody drug development technologies with novel antibody formats 

  • Responsible for antibody discovery immunization strategy and candidate validation 

  • Lead antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs). 

  • Use structural and sequence analysis to guide the design of drug candidates 

  • Oversee drug candidate optimization, selection, validation, and stability study 

  • Contributions to regulatory filings of biotherapeutics 

  • Review and authorize Standard Operating Procedures (SOP)  

  • Prepare reports and papers of completed projects for publication in technical journals, patents, presentation to regulatory agencies or at conferences, or use in further research activities. 

  • Support and closely work with other departments 

  • Work with R&D center in China. Plan time to accommodate meetings and technical support with team members in China  

  • Support scientific discussions, high-level strategic scientific advice, inputs, and expertise to management, the Board, advisory groups, and scientific committees. 

  • Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects. 

  • Other duties as assigned. 

Qualifications: 

To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. 

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