Associate Scientist / Scientist / Senior Scientist - Protein Engineering

Redmond, WA

About the position

The Research Associate/Associate Scientist/Scientist/Senior Scientist is responsible for monitoring and coordinating activities in the research lab. The position requires extensive experience in antibody-based therapeutics, protein engineering, molecular biology, purification, and characterization.

Essential Duties and Responsibilities

  • Participate in antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs).
  • Use structural and sequence analysis to guide the design of proteins and expression plasmids.
  • Perform duties in cloning, mammalian cell line expression, purification, and characterization of protein constructs.
  • Humanize antibodies based on knowledge of CDR grafting, germ lining, and structural/sequence homology.
  • Engineer PTM sites using structure-guided approach.
  • Participate in candidate optimization, selection, and validation.
  • Use computer software to generate homology models and evaluate their properties via in silico simulation.
  • Perform protein analytics such as biolayer interferometry, dynamic light scattering, SDS-PAGE, and HPLC.
  • Utilize computer software including Pymol, Chimera, IgBlast, Discovery Studio, abYsis, and Geneious.
  • Write and review Standard Operating Procedures (SOP) for regulatory filing, laboratory duties, experiment design, data analysis, instruction operation, and maintenance.
  • Support and closely work with other divisions to advance company goals.
  • Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China.
  • Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects.
  • Other duties as assigned.

Qualifications

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education & Experience (Associate Scientist/Scientist/Senior Scientist)
  • Ph.D. or M.S. degree with four or more years of experience in protein engineering.
  • Strong scientific background in structural biology, molecular biology, biochemistry, protein purification and characterization.
  • Experience in antibody engineering is desired.
Education & Experience (Research Associate)
  • M.S. or B.S. degree with two additional years of experience in cloning, protein expression, purification, and analytics
  • Strong scientific background in structural biology, molecular biology, biochemistry, protein purification and characterization.
Language Ability
  • Ability to read and comprehend simple instructions, short correspondence, and memos.
  • Ability to write simple correspondence.
  • Ability to effectively present information in one-on-one and small group situations to customers, clients, and other employees of the organization.
  • Strong interpersonal, communication, and collaboration skills to connect with internal and external CROs.
  • Ability to read or write in Mandarin is a plus.
Math Ability
  • Ability to calculate figures and amounts such as discounts, interest, commissions, proportions, percentages, area, circumference, and volume.
  • Ability to apply concepts of basic algebra and geometry.
Reasoning Ability
  • Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form.
  • Strong scientific, medical, and analytical abilities with innovative, solution-oriented style.
Computer Skills

Proficiency with Microsoft Word, Excel, and Access required. Proficiency with email required.

Certificates and Licenses

None required.

Supervisory Responsibilities

This job may have supervisory responsibilities.

Work Environment
  • The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
  • This individual will work in cell culture and molecular biology laboratories alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.
Physical Demands
  • The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
  • While performing the duties of this job, the employee is regularly required to sit for long periods of time. This individual must be able to handle, assemble and manipulate bioreactor components and operate standard laboratory and business equipment.
  • Are you interested in this position? Apply now