Principal Scientist - Antibody Discovery

Redmond, WA

Summary: We have an opportunity for a highly motivated Principal Scientist with expertise in antibody discovery to join our team in Redmond, WA. This position will contribute to the development of cancer therapeutics through the generation and selection of antibody candidates. This onsite, lab-based role will work closely with experienced scientists in a dynamic, fast-paced and highly collaborative environment. 

Essential Duties and Responsibilities: 

  • Manage staff and contribute within the antibody discovery group, operating both established B cell culture, and yeast display-based antibody discovery platforms 

  • Incorporate new methods and technologies toward immunogen engineering or compositions suited toward the therapeutic aims of each antibody campaigns  

  • Use a variety of high throughput methods to characterize antibody biochemical, biophysical properties, functional and comparative features 

  • Supervise antibody sequence rescue, sequencing and in silco analyses related to therapeutic developability 

  • Expertly analyze experimental data and present scientific interpretation in group meetings 

  • Cooperate with other R&D departments to utilize scientific and laboratory resources effectively 

  • Develop strategies, identify priorities, establish timelines, to advance multiple discovery programs 

Education/Experience 

  • PhD in Molecular Biology, Immunology, or related discipline with a minimum of 8 years of relevant experience, preferably in a biotech or pharmaceutical setting. 

  • Background in B cell culture-based antibody discovery methods required. Experience using yeast libraries to generate therapeutic antibodies is a plus. 

  • Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET). 

  • Proven contribution to therapeutic antibody development and selection is highly desirable.  Discovery of novel and biologically relevant antibodies highly desirable. 

Are you interested in this position? Apply now