Senior Scientist - Upstream
Redmond, WA
Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic bi-specific, and tri-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.
Position Summary:
We are seeking a highly skilled and motivated Upstream Senior Scientist to join our team onsite in Redmond, WA. This individual will lead and execute upstream project process development (USP) and technology transfer activities to support the development of clinical manufacturing processes for our protein therapeutics pipeline. The ideal candidate will have hands-on experience with mammalian cell culture, bioreactor operations, and process scale-up for biologics production.
Major Responsibilities:
- Apply technical knowledge andin upstream process development for CHO cells (bioreactor process design, scale up, media and feed optimization, etc.), draft study protocol, design and execute experiments including in-process tests, characterize and deliver harvest material to downstream team,and author technical reports.
- Stay abreast of technical advancements in the CMC area of CHO cell line development and upstream process development and technology transfer aligned with cGMP clinical manufacturing.
- Support the transfer, development, and scale-up of CHO cell culture process technology from research into process development and manufacturing, to enable the production of clinical material
- Collaborate with teams in downstream process development and analytical development to advance recombinant protein programs
- Lead and support various elements of early-stage CMC development activities, including technical support of non-GMP and clinical manufacturing, as well as development and implementation of process improvements, as programs advance through development
- Analyze, interpret, present and document complex technical information in statistically meaningful ways. Exhibit and improvein DoE and multi variant analysis.
- Work with the team within the project scope, manage timeline in a fast-paced dynamic environment with rigor and agility.
- Data analysis, interpretation, and effective communication to management.
Qualifications and Experience:
- PhD. with 4+ years of work experience in upstream bioprocess.
- Significant technicalbioreactor use, optimization, and scale-up. DasGip or DASware experience is desired. Perfusion experience is a plus.
- Ability to work independently to troubleshoot processes and develop new methods in a flat, collaborative matrix.
- Experience in scaling up and technology transfer to manufacturing environment and understand GMP well.
- Experience and knowledge in other sections of therapeutic protein process development, including downstream, formulation, analytics, are valued.
- Exceptional communication and interpersonal skills to positive relationships with stakeholders.
- Proactively introduce new methods, provide technical mentorship to colleagues, and identify and execute ways to keep lab running efficiently
- Accuracy and attention to detail
- Ability to work on multiple projects simultaneously
This job description is intended to present the general content and requirements for this job. The description is not to be construed as an exhaustive statement of duties, responsibilities, or requirements. Managers and supervisors may assign other duties as needed.
The hiring pay range for this position is $100,000 - $185,000 per year based on skills, education, and experience relevant to the role.
SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.
SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to [email protected]
