Scientist / Senior Scientist - Protein Engineering

Redmond, WA

About the position:
The Scientist/Senior Scientist is responsible for monitoring and coordinating activities in the research lab. The position requires extensive experience in antibody-based therapeutics, protein engineering, molecular biology, purification, and characterization.

Essential Duties and Responsibilities: 

• Participate in antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs).
• Use structural and sequence analysis to guide the design of proteins and expression plasmids.
• Perform duties in cloning, mammalian cell line expression, purification, and characterization of protein constructs.
• Humanize antibodies based on knowledge of CDR grafting, germ lining, and structural/sequence homology.
• Engineer PTM sites using structure-guided approach.
• Participate in candidate optimization, selection, and validation.
• Use computer software to generate homology models and evaluate their properties via in silico simulation.
• Perform protein analytics such as biolayer interferometry, dynamic light scattering, SDS-PAGE, and HPLC.
  
• Utilize computer software including Pymol, Chimera, IgBlast, Discovery Studio, abYsis, and Geneious.
• Write and review Standard Operating Procedures (SOP) for regulatory filing, laboratory duties, experiment design, data analysis, instruction operation, and maintenance.
• Support and closely work with other divisions to advance company goals.
• Work with R&D and manufacturing department in China. Plan time to accommodate meetings and technical support with team members in China.
• Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects.
• Other duties as assigned.

Qualifications: 

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Education & Experience (Scientist/Senior Scientist)

• Ph.D. or M.S. degree with four or more years of experience in protein engineering.
• Strong scientific background in structural biology, molecular biology, biochemistry, protein purification and characterization.
• Experience in antibody engineering is desired.

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to [email protected]

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