Scientist/Sr. Scientist - Upstream Process Development

Redmond, WA

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

Summary: SystImmune seeks a Scientist/Sr. Scientist in Cell Science Development with a strong background in mammalian cell culture and protein expression. The successful candidate will be highly motivated and have direct experience with methods and processes designed in bioreactor to support early-stage upstream cGMP manufacturing.

Essential Duties and Responsibilities: 

• Independently design and execute protocols for scalable stable expression of recombinant proteins in CHO cells
• Use statistical design of experiments approaches to optimize protein production using re-usable bioreactor (3L or 15L); perform bioreactor activities such as inoculation, feeding, sampling, and harvesting
• Perform upstream duties, including but not limited to media preparation, cell culture analyzer operation and maintenance, bioreactor assembly and cleaning
• Support the cell line development (CLD) team through participation in vector cloning, stable transfection, minipool selection, single cell cloning, expansion, and characterization of CHO cells for recombinant protein production
• Prepare SOP and maintain lab instruments for upstream processing
• Interpret data independently, and contributes to technical reports, including technology transfer if needed
• Coordinate within department as well as cross functionally with peers on projects
• Work on weekend/holiday if needed
  

Qualifications: 

Education and Experience:

• PhD with 3+ years, or a MS with 10+ years of experience in cell culture
• Experience with upstream process development is required
• Strong scientific understanding of recombinant protein expression in bioreactor, cell line development, cellular metabolism and media optimization
• Experience in early and late-stage biologic development is plus
• Excellent communication skills and a proven track record of IND filing, publications and presentations

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. Interested applicants should send their CV and cover letter to [email protected]

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